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MDM-Portal (Medical Data-Models) is a meta-data registry for creating, analysing, sharing and reusing medical forms, developed by the Institute of Medical Informatics, Heidelberg University Hospital in Germany. see also https://doi.org/10.1055/s-0044-1786839 Electronic forms for documentation of patient data are an integral part within the workflow of physicians. A huge amount of data is collected either through routine documentation forms (EHRs) for electronic health records or as case report forms (CRFs) for clinical trials. This raises major scientific challenges for health care, since different health information systems are not necessarily compatible with each other and thus information exchange of structured data is hampered. Software vendors provide a variety of individual documentation forms according to their standard contracts, which function as isolated applications. Furthermore, free availability of those forms is rarely the case. Currently less than 5 % of medical forms are freely accessible. Based on this lack of transparency harmonization of data models in health care is extremely cumbersome, thus work and know-how of completed clinical trials and routine documentation in hospitals are hard to be re-used. The MDM-Portal serves as an infrastructure for academic (non-commercial) medical research to contribute a solution to this problem. It already contains more than 25,000 system-independent forms (CDISC ODM Format, www.cdisc.org, Operational Data Model) with more than 600,000 data-elements. This enables researchers to view, discuss, download and export forms in most common technical formats such as PDF, CSV, Excel, SQL, SPSS, R, etc. A growing user community will lead to a growing database of medical forms. In this matter, we would like to encourage all medical researchers to register and add forms and discuss existing forms.

Paramecia are unicellular eukaryotes of large size (~ 120 micrometers for P aurelia species) that belong to the ciliate phylum. Ciliates, like the Last Eukaryotic Common Ancestor, have the axonemal structure in the form of vibrating cilia that assure locomotion and food capture and are essential for pairing of paramecia of opposite mating types during conjugation (sexual reproduction). Like multicellular eukaryotes, ciliates separate germinal and somatic functions, harbouring two different kinds of nuclei. A diploid germinal micronucleus transmits the genetic information to the next sexual generation, while a polyploid somatic macronucleus is responsible for gene expression. Reproducible DNA elimination, which occurs in many animal lineages, takes place in ciliates during sexual reproduction, when a new somatic macronucleus develops from a copy of the germline micronucleus. The somatic genomes of numerous Paramecium species are being sequenced and annotated. ParameciumDB integrates the genomes as they become available, to provide resources for functional and comparative genomics to the community. ParameciumDB interfaces and tools have been redesigned. Your feedback is welcome.

This site provides access to Grey Literature from Europe. The interface is available in French and English. This site replaces OpenSIGLE. The content is available in a variety of European languages.

The ETOX database allows access to effects information from aquatic and terrestrial ecotoxicology. Furthermore, ETOX contains information on various national and international environmental quality guidelines, targets, standards, criteria, and limit values. In focus are substances which are relevant for assessment of surface water pollution to trigger the development of environmental quality standards according to Water Framework Directive 60/2000/EC.