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- Data Repository United States Compatibility:Not yet registeredPartners:Department of Environmental and Public Health Sciences, University of Cincinnati Life Science, Epigenomics, ToxicologyDepartment of Environmental and Public Health Sciences, University of Cincinnati
The Chromium Epigenomics Toxicology (EpiCrDB) database contains a variety of epigenomics experimental assays relating to research on how Cr(VI) perturbs chromatin organization and dynamics. This data is used in reseach into how its toxicity may be attributed to epigenetic carcinogenicity. Manually-annotated sample and experiment metadata is included to facilitate FAIR data access. Hexavalent chromium [Cr(VI)] compounds are well-established respiratory carcinogens utilized in industrial processes. While inhalation exposure constitutes an occupational risk affecting mostly chromium workers, environmental exposure from drinking water contamination is a widespread gastrointestinal carcinogen, affecting millions of people throughout the world. The mechanism of action of Cr(VI) at the molecular level is poorly understood.
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Wikidata is a free and open knowledge base that can be read and edited by both humans and machines. Wikidata acts as central storage for the structured data of its Wikimedia sister projects including Wikipedia, Wikivoyage, Wiktionary, Wikisource, and others. Wikidata also provides support to many other sites and services beyond just Wikimedia projects. The content of Wikidata is available under a free license, exported using standard formats, and can be interlinked to other open data sets on the linked data web.
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The COVID-19 host genetics initiative brings together the human genetics community to generate, share, and analyze data to learn the genetic determinants of COVID-19 susceptibility, severity, and outcomes. Such discoveries could help to generate hypotheses for drug repurposing, identify individuals at unusually high or low risk, and contribute to global knowledge of the biology of SARS-CoV-2 infection and disease.
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- Data Repository United States Compatibility:Not yet registeredPartners:Department of Environmental and Public Health Sciences, University of Cincinnati Life Science, Epigenomics, ToxicologyDepartment of Environmental and Public Health Sciences, University of Cincinnati
The Chromium Epigenomics Toxicology (EpiCrDB) database contains a variety of epigenomics experimental assays relating to research on how Cr(VI) perturbs chromatin organization and dynamics. This data is used in reseach into how its toxicity may be attributed to epigenetic carcinogenicity. Manually-annotated sample and experiment metadata is included to facilitate FAIR data access. Hexavalent chromium [Cr(VI)] compounds are well-established respiratory carcinogens utilized in industrial processes. While inhalation exposure constitutes an occupational risk affecting mostly chromium workers, environmental exposure from drinking water contamination is a widespread gastrointestinal carcinogen, affecting millions of people throughout the world. The mechanism of action of Cr(VI) at the molecular level is poorly understood.
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The COVID-19 host genetics initiative brings together the human genetics community to generate, share, and analyze data to learn the genetic determinants of COVID-19 susceptibility, severity, and outcomes. Such discoveries could help to generate hypotheses for drug repurposing, identify individuals at unusually high or low risk, and contribute to global knowledge of the biology of SARS-CoV-2 infection and disease.
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