Drug Mechanism Database (DrugMechDB) compiles curated mechanism of action linking a drug to a disease. Most drug mechanisms are described simply as a protein target, or a pathway, that then treats the disease. However, there are usually more steps across a biological knowledge graph required to traverse from the target through its mechanism to the reduction of a disease. DrugMechDB catalog a subset of known drug-disease indications as a path through a network of biomedical entities.