The Common Fund’s Gabriella Miller Kids First Pediatric Research Program (Kids First) has developed the Kids First Data Resource, a large-scale data resource to help researchers uncover new insights into the biology of childhood cancer and structural birth defects. It provides clinically annotated genomic data and is integrated with several tools to accelerate pediatric disease research. The Kids First Data Resource Portal allows users to query, or search, Kids First datasets, build virtual cohorts, or collections, of individual participants, and identify datasets for analysis. CAVATICA, built by Seven Bridges Genomics, allows users to run bioinformatics workflows in a cloud-based environment.