The World Health Organisation says that there are about 100 million people globally who need prosthetic or orthotic (P&O) services and as populations age, more than two billion people are expected to require health-related assistive devices by 2030. In the UK the Disabled Living Foundation estimates that 6.5 million people live with mobility disablement, with many reliant on P&O services, including an estimated two million orthotic users. In parts of the developing world the aftermath of conflict, such as land mines, and greater rates of traumatic injuries from accidents, means there is a growing need for prosthetics and orthotics for younger people living in poor social and economic circumstances. Often they need P&O devices to stay at work and sustain their families. Poor devices, services and access to these contravene their basic human rights. In the context of this need, we want to establish the EPSRC Centre for Doctoral Training in P&O. This will address the national, and global, shortage of suitably skilled engineers and scientists to become future innovators in P&O technologies. Current academia, industry and care centres have limited researchers, and research activity has lagged behind rapid technology advancements. The Centre will support a minimum of 58 doctoral students whose studies will enable them to become leaders of the future. The Centre will bring together the only two P&O undergraduate education facilities in the UK (Salford and Strathclyde) with P&O research centres of excellence at Imperial College and the University of Southampton. Our vision is for the Centre to become the national and global leader in P&O research training, and the translation of research into innovation that impacts on the lives of people each day, in developed and developing countries. The Centre will work to support training for students from low and middle-income countries (LMIC). Our students will be immersed in industry and real-world experiences which will equip them to lead the P&O sector across technology, social or economic contexts. Our aims are to: 1. Develop a new model of P&O research training and translation of research into innovation. In addition to the doctoral training, this will result in Master's programmes operating across Institutions. 2. Produce ambitious PhD research projects that will be grounded in real-world challenges, but at the cutting-edge of new biomedical science and technologies. 3. Produce a significant impact on the UK P&O industry sector by leading innovation. 4. Have an international impact by attracting an increasing number of CDT students from overseas. 5. Establish a P&O student society which will have matured into a lasting doctoral community with international reach. 6. To have a significant impact on the training of doctoral candidates from LMIC. 7. Attract additional external funding for P&O research. Creating a new generation of P&O research leaders will, over time, have a significant economic, societal and health impact. For users, it will mean access to improved generations of assistive devices which will match the users' needs resulting in a better quality of life. Clinical services will benefit from improved service data, superior products and improved user outcomes. For industry, it will open up new market opportunities, nationally and globally. For the students themselves, they will have access to careers that have a real purpose, enabling them and their future teams to make a difference in the lives of people with disabilities.