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The overall objective of HILIGHT is to implement innovative solutions into versatile light sources and systems as tools for biomedical and healthcare applications centred around two-photon excitation fluorescence lifetime measurements and imaging microscopy. We propose two specific use cases: i) instantaneous digital histopathology and ii) biomedical research in the context of cancer research and diagnostics. HILIGHT proposes a miniaturised and versatile optical pulse burst source together with innovative sensing technology that will permit us to overcome those limitations in SoA instrumentation that often confine the use of two-photon microscopy and timeresolved detection to the specialist laboratory. We envisage that the HILIGHT innovations could disrupt activities in various fields and a range of market segments, including academic and research institutions, biotechnology, and medical facilities. These include applications targeted to improve our understanding of the molecular mechanisms of disease using in vivo, ex vivo, or 3D organotypic cultures, with the ultimate aim of developing better tools for fast and early diagnosis and more effective therapeutic interventions. HILIGHT is structured around nine work packages covering the whole value chain, coherently with the concept of the project standing on strong enabling technology foundations and targeting biophotonic and medical application domains. HILIGHT consortium is made up of five leading partners from various fields experienced in European collaborative projects and from five different European countries (FR, DE, IT, CH and UK). HILIGHT is built on several prior and ongoing successful collaborations between partners, which provides a strong guarantee for successful interaction within the consortium, and a smooth implementation of the workplan.

To develop advanced computational models for the design of exhaust silencers for gas turbines, with the aim of improving turbine efficiency.

Integrate sensing and communication (ISAC), which enables the radar sensing and wireless communication to be integrated to share the spectrum, hardware infrastructure and signal processing architectures, has been recognized as one promising technical supporter of providing spectrum- and energy-efficiency services for 6G network. However, due to the shared usage of the spectrum and broadcast nature of wireless medium, ISAC systems are facing multiple security threats and attacks that may result in information leakage, service outage and network congestion. To address above security issues, in this project, we propose a novel secure ISAC (S ISAC) framework for future wireless networks aimed at providing secure and reliable communication services with precise and accurate sensing simultaneously in the following three work packages. In the first work package (WP), a covert ISAC framework will be proposed to hide the communication signal into multiple other signals, including radar signal, noise signal and jamming signal and ensure the covert communication without being detected by the malicious adversary. Next, efficient physical layer security (PLS) strategies will be developed in the second WP to against the passive eavesdropping attacks, which are launched by half-duplex eavesdroppers with the capability of decoding the communication signals. Then, to against more harmful active eavesdropping attacks that are launched by full-duplex eavesdroppers who are capable of overhearing the communication signal and sending malicious jamming signal simultaneously, robust PLS strategies will be designed by satisfying the sensing requirements in the third WP. Finally, extensive simulation results will be provided to validate the effectiveness and robustness of our proposed S-ISAC design.

Artificial sweeteners are a group of compounds that have a significantly higher sweetening power than sucrose but have little to no calorific contribution. Because of these properties, artificial sweeteners have become mainstays in the human diet with many companies offering "Zero" or "Sugar Free" alternatives to typically high sugar products. While there have been extensive studies investigating the impact of these sweeteners on the human body (Carocho et al., 2017), there have been relatively few studies looking at the impact of these compounds on the bacteria in the human body. However, these is emerging evidence that artificial sweeteners can significantly alter the gut and oral microbiome and that these changes can have an impact on human health (Suez et al., 2022). A recent study by the McCarthy lab has demonstrated that a number of these artificial sweeteners possess antimicrobial properties with the highly popular sweetener acesulfame K (ace-K) in particular, being able to inhibit bacterial movement, their ability to acquire antibiotic resistance genes from the environment and their ability to grow (De Dios et al., 2023). In this project we want to repurpose this sweetener as an infection and contamination control agent.