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1,046 Projects, page 1 of 210
  • Funder: European Commission Project Code: 302157
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  • Funder: European Commission Project Code: 101065137
    Funder Contribution: 189,687 EUR

    Today’s technology for the biocatalytic production of base chemicals is fossil-fuel based. Moving away from non-renewable and carbon-based energy feedstocks towards renewable hydrogen is a key challenge for current chemical processes. However, biocatalysis has yet to see H2 implemented as a energy source, simply because such H2-consuming reactions are sensitive to O2, whereas many enzymatic reactions driving product formation require O2 as a cosubstrate. H2-driven biocatalysis is not realized today on a large scale because of this need for both O2-sensitive and O2-dependent reactions to operate in tandem. The goal of this Marie Skłodowska-Curie Postdoctoral Fellowship project is to deliver the theoretical framework and experimental validation for novel biohybrid catalytic microdisks capable of carrying out seemingly incompatible tandem reactions by controlling the spatial separation of reaction layers (ReLay). Driven by both theory and simulation, the optimal conditions will be found to create both anaerobic and aerobic domains allowing O2-sensitive and O2-dependent reactions to take place within a single particle. This will be accomplished by, first, building a reaction-diffusion model and simulation toolbox to establish the theoretical framework of spatially separated reaction layers in these catalytic micodisks. Second, the parameter space will be explored using the model and simulations to find the best performing components and conditions. Finally, these predictions will be validated with an experimental case-study, comparing the expected output from the model with the actual reaction rates and concentrations gradients measured experimentally for an O2-dependent oxyfunctionalization driven by H2 within the catalytic microdisks. These actions will create a universal platform for H2-driven biocatalysis, which can be implemented directly in current bioreactors.

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  • Funder: European Commission Project Code: 101188487
    Funder Contribution: 150,000 EUR

    CERES aims at evaluating possible commercial applications of new protein-based down-converting red-emitting LED sources. Laboratory prototypes exhibit an extraordinary stability and efficiency as well as an easy-to-tune emission spectrum. This contrasts with the commercial low-energy emitting LED technology. CERES will focus on a validation phase including i) the optimization of the upscaling of protein production, the preparation of large-area protein-polymer color filters, and the assembly of red-emitting LED arrays and ii) the test in pre-industrial crop controlled environment agriculture growing boxes. This information will be paramount to realize a realistic market impact.

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  • Funder: European Commission Project Code: 101163999
    Overall Budget: 1,499,970 EURFunder Contribution: 1,499,970 EUR

    LaserCell envisions an innovative approach to reshape and rearrange cellulose at the molecular level by disrupting cohesive interactions through resonant excitation of specific bonds. It will revolutionize the field of biopolymer processing beyond cellulose and yield fundamental insights into supramolecular structure and dynamics in biomaterials. Although cellulose is biodegradable and mechanically strong, it cannot be processed by conventional thermoplastic polymer methods, which limits its use as high-volume material. Cellulose decomposes before it melts because of cooperative intermolecular hydrogen bonding and hydrophobic interactions. To plasticise cellulose, I propose to disrupt these intermolecular bonds with photon energy delivered by infrared (IR) laser pulses. Employing wavelengths matching specific vibrational modes, the photon energy will be resonantly absorbed, thus effectively plasticising cellulose. I envision that the rapid energy dissipation in short pulses will deliver enough peak power to disrupt the intermolecular bonds yet avoiding thermal damage. I plan to systematically investigate how laser parameters influence the supramolecular structure of cellulose and establish analytical tools to characterize its structural transitions under mechanical load. Additionally, to allow processability in different set-ups, I aim to prolong the time window of plasticization and adjust the flowability, by using the laser irradiation in synergy with the hydrogen disrupting molecules. As a proof of concept, I will implement this novel photo-plasticization technique into a cellulose fibre spinning process and post-treatment to modulate the cellulose fibre crystallinity. I have worked for 10 years on cellulose-based materials and have a strong background in fibre spinning and material science. My research group will engage 1 PhD student and 2 Postdocs with background in polymer science and laser physics and technology.

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  • Funder: European Commission Project Code: 787367
    Overall Budget: 2,354,000 EURFunder Contribution: 2,354,000 EUR

    Parameterized systems consist of an arbitrary number of replicated agents with limited computational power, interacting to achieve common goals. They pervade computer science. Classical examples include families of digital circuits, distributed algorithms for leader election or byzantine agreement, routing algorithms, and multithreaded programs. Modern examples exhibit stochastic interaction between mobile agents, and include robot swarms, molecular computers, and cooperating ant colonies. A parameterized system is in fact an infinite collection of systems, one for each number of agents. Current verification technology of industrial strength can only check correctness of a few instances of this collection. For example, model checkers can automatically prove a distributed algorithm correct for a small number of processes, but not for any number. While substantial progress has been made on the theory and applications of parameterized verification, in order to achieve large impact the field has to face three ``grand challenges'': - Develop novel algorithms and tools for p-verification of classical p-systems that bypass the high complexity of current techniques. -Develop the first algorithms and tools for p-verification of modern stochastic p-systems. -Develop the first algorithms and tools for synthesis of correct-by-construction p-systems. Addressing these challenges requires fundamentally new lines of attack. The starting point of PaVeS are two recent breakthroughs in the theory of Petri nets and Vector Addition Systems, one of them achieved by the PI and his co-authors. PaVeS will develop these lines into theory, algorithms, and tools for p-verification and p-synthesis, leading to a new generation of verifiers and synthesizers.

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