Europe has witnessed a significant rise in the frequency and severity of extreme weather events, and especially the broader Mediterranean region showcases the devastating consequences of climate-related disruptions. CLIMRES aims to foster a ‘Leadership foEurope has witnessed a significant rise in the frequency and severity of extreme weather events, and especially the broader Mediterranean region showcases the devastating consequences of climate-related disruptions. Unseasonably warm temperatures during the winter months are increasingly becoming a pattern, disrupting traditional weather patterns and ecosystems. CLIMRES aims to foster a ‘Leadership for Climate Resilient Buildings’, by addressing the identification and systematic categorisation of buildings’ vulnerabilities and estimating their impact in the buildings' ecosystem considering the interlinkages within the urban context. The project will deliver vulnerability assessment and impact evaluation methodologies along with an inventory hub of measures for building materials and design against climate risks and a decision support toolkit addressing three levels of decision making at strategic, tactical and operational levels. CLIMRES solutions will be tested in 3 large scale pilots in Spain, Greece, Italy and Slovenia evaluating their efficacy against heatwaves, extreme flooding, fires and earthquakes and one multi-hazard replication multiplier pilot in France. The experiences and lessons learnt from the extensive pilot evaluation will consult the replication roadmap of the project as well as a capacity building programme that will train the next frontier leaders for climate resilient buildings. Overall, the CLIMRES Leadership will provide valuable insights and guidance for building owners, policymakers, and stakeholders involved in building climate resilience and sustainable development, through the co-creation, development, deployment and demonstration at TRL 6-8 highly cost-effective and replicable solutions.