
NATIONAL INSTITUTE FOR COMMUNICABLEDISEASES
NATIONAL INSTITUTE FOR COMMUNICABLEDISEASES
10 Projects, page 1 of 2
Open Access Mandate for Publications and Research data assignment_turned_in Project2024 - 2026Partners:INRB, UCB, NATIONAL INSTITUTE FOR COMMUNICABLEDISEASES, UNHRO, Makerere University +2 partnersINRB,UCB,NATIONAL INSTITUTE FOR COMMUNICABLEDISEASES,UNHRO,Makerere University,University of Liverpool,McMaster UniversityFunder: European Commission Project Code: 101194676Overall Budget: 1,260,000 EURFunder Contribution: 1,260,000 EURBackground: Monkeypox virus (MPV) is a member of the Poxviridae family that includes smallpox, cowpox and chickenpox viruses. Endemic to equatorial Africa following casual human to animal or human to human transmission , recent events have seen an increased incidence with indications of sexual transmission. The disease is characterized by fever, muscle aches, skin rash, lymphadenopathy, oral sores, sore throat, cough, etc. Within any cluster of high risk contacts of a case mpox; however, not everyone exposed develops clinical disease. Moreover, among those contacts who develop mpox, not everyone gets severe disease or dies. Hypothesis: Host genetic & viral factors explain the differential outcomes following exposure to MPV. Objectives: To determine the host genetic and viral determinants of mpox disease in Kamituga area, South Kivu province, DRC. Specifically, we will (I) establish well phenotyped cohorts of house-hold contacts, (II) determine rare variants via family trios; (III) undertake RNASeq for transcriptomics, and (IV) study differential cellular immunity profiles using digital cell sorting (DCS) , (V) identify viral variants that drive severe disease Methods: Whole exome sequencing (WES), transcriptomics and DCS studies of house-family contacts clinically prequalified by PCR and serological testing. Virus gDNA will be reverse transcribed from sequenced host RNA and characterized by comparative genomics and phylogeny. Potential impact: This project will elucidate host genetic & viral determinants of susceptibility to mpox disease in context of natural exposure and infection; that may serve as correlates of immune protection following vaccination.
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For further information contact us at helpdesk@openaire.euOpen Access Mandate for Publications and Research data assignment_turned_in Project2024 - 2026Partners:Philipps-University of Marburg, NATIONAL INSTITUTE FOR COMMUNICABLEDISEASES, NNGYK, INSERM, DH +8 partnersPhilipps-University of Marburg,NATIONAL INSTITUTE FOR COMMUNICABLEDISEASES,NNGYK,INSERM,DH,DDPS,INSTITUTO NACIONAL DE SAUDE DR. RICARDO JORGE,FoHM,CSIRO,ISCIII,ERINHA,MEDICAL UNIVERSITY OF GRAZ,Istituto Nazionale per le Malattie Infettive Lazzaro SpallanzaniFunder: European Commission Project Code: 101132215Funder Contribution: 1,498,080 EUREmerging infectious diseases (EID) do not respect borders. They rank as global catastrophic risks for humanity, along with climate change and biodiversity loss. The COVID-19 pandemic showed how coordination of global research, through cooperation, and sharing of data and expertise, are crucial for efficient and effective preparedness to EIDs, and vital for a rapid response. Nevertheless, there are still major challenges limiting global cooperation among high containment laboratories (HCLs). HCLs are critical infrastructures for the development of medical countermeasures (e.g., vaccines and therapeutics) against high consequence pathogens. In order to fulfil its role, and given the global threat of EIDs, the European Research Infrastructure on Highly pathogenic Agents (ERINHA), together with its partners, proposes to establish and reinforce interactions with HCL research infrastructures (RI) worldwide, to strengthen pandemic preparedness and response capacities. INTERCEPTOR (INTERnational Cooperation of high containment research infrastructures: from Epidemic Preparedness TO Response), a consortium with key HCLs from Europe and across the world, will focus on access provision to HCLs, enhancement of the human capital of HCL, including in biorisk management, critical resources sharing, harmonisation and interoperability. The proposed actions will help ensure broader access to state-of-the-art HC facilities, while respecting the necessary biosecurity and biosafety constraints, and promote the establishment of a sustainable global network of HC RIs. By expanding access to HC RIs, strengthening the human capital base, promoting sharing of knowledge, skills and experience, and providing opportunities for common training programmes and staff exchanges, INTERCEPTOR will reinforce the next generation of HCL researchers and facility managers, and extend the opportunities for access to HCLs, required to push the boundaries of science and innovation in the field of EIDs.
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For further information contact us at helpdesk@openaire.euOpen Access Mandate for Publications and Research data assignment_turned_in Project2023 - 2027Partners:UNAM, NATIONAL INSTITUTE FOR COMMUNICABLEDISEASES, LSHTM, LG, UNSTIM +8 partnersUNAM,NATIONAL INSTITUTE FOR COMMUNICABLEDISEASES,LSHTM,LG,UNSTIM,NIMR,CERMEL,DSMZ,FZB,KONINKLIJKE NEDERLANDSE CENTRALE VERENIGING TOT BESTRIJDING DER TUBERCULOSE (KNCV),IHI,University of Ghana,INSFunder: European Commission Project Code: 101103174Overall Budget: 4,998,430 EURFunder Contribution: 4,998,430 EURThe main aim of the proposed project is to use genomic epidemiology of tuberculosis, malaria and emerging and re-emerging pathogens in Africa as to better understand disease etiology, dynamics of disease transmission, and evolution of drug-resistant pathogens. The study also aims to increase Africa's capacity in bioinformatics, genomics, genomics data management, biobanking, and promote data sharing. Our goal is to improve the health of Africans with innovations in disease surveillance, equip the next generation of African scientists with cutting edge skills and strengthening south-south research collaborations. We propose the following hypotheses: 1. Increased capacity in genomic epidemiology will enable more effective disease surveillance in Africa. 2. Increased capacity in biobanking and genomics data management and analysis in Africa will enhance regional surveillance of infectious diseases and encourage timely and effective responses to emerging pathogens. 3. Regional whole genome sequence-based surveillance will improve the detection of DR-TB and inform the development of more sensitive and specific rapid diagnostics for the detection and surveillance of DR-TB in Africa and elsewhere. 4. Regional genomic surveillance of malaria parasites will inform a pre-emptive detection of emerging DR parasites and measure the impact of programmatic interventions for a data driven decision making by policy makers. 5. Implementation of harmonized genomic data analysis tools will allow the creation of continent-wide surveillance networks able to identify cross-border spread of DR variants and emerging pathogens. To achieve this, PANGenS will develop genomic epidemiology capacity across Africa by establishing a collaborative framework that brings together all expertise to perform trainings and implementation in all relevant components ranging from wet lab to bioinformatics, and establish proof-of-concept studies for TB and malaria in in selected partner countries
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For further information contact us at helpdesk@openaire.euOpen Access Mandate for Publications assignment_turned_in Project2010 - 2015Partners:UL, NATIONAL INSTITUTE FOR COMMUNICABLEDISEASES, Philipps-University of Marburg, University of Stirling, UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS +12 partnersUL,NATIONAL INSTITUTE FOR COMMUNICABLEDISEASES,Philipps-University of Marburg,University of Stirling,UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS,BGU,Aristotle University of Thessaloniki,FoHM,KUL,Coris BioConcept (Belgium),Inserm Transfert,FoHM,CDC Foundation,INSTITUTE OF PUBLIC HEALTH,NCIPD,Ministry of Health,SVAFunder: European Commission Project Code: 260427All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=corda_______::f873aeaec6ed52f5d0ec9eabba4c297a&type=result"></script>'); --> </script>
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For further information contact us at helpdesk@openaire.euOpen Access Mandate for Publications assignment_turned_in Project2016 - 2019Partners:Duke University, EPSRC, Ca Foscari University of Venice, RIVM, UH +21 partnersDuke University,EPSRC,Ca Foscari University of Venice,RIVM,UH,NIA,GAIKER,LEITAT,NATIONAL INSTITUTE FOR COMMUNICABLEDISEASES,NERC,RTI International,INERIS,Misvik Biology Oy,GREENDECISION SRL,DTU,R-Tech,KI,DIALOGIK GEMEINNUETZIGE GESELLSCHAFT FUER KOMMUNIKATIONS- UND KOOPERATIONSFORSCHUNG mbH,TAMPERE UNIVERSITY OF TECHNOLOGY,FIOH,TAMPERE UNIVERSITY,AIRI,TNO,EMPA,NRCWE NFA,EAWAGFunder: European Commission Project Code: 686239Overall Budget: 9,828,110 EURFunder Contribution: 7,999,690 EURThe objective of the caLIBRAte project is to establish a state-of-the-art versatile Risk Governance framework for assessment and management of human and environmental risks of MN and MN-enabled products. The framework will be a web-based “system-of-systems” linking different models and methods for: 1) screening of apparent and perceived risks and trends in nanotechnology, 2) control banding, qualitative and fully integrated predictive quantitative risk assessment operational at different information levels, 3) safety-by-design and multi-criteria decision support methods, 4) risk surveillance, -management and -guidance documents. The risk management framework will support assessments of emerging and existing MN and MN-enabled products following the recent ISO31000 risk governance framework, as well as safety in innovation by matching models to the principle innovation steps in the “Cooper Stage-Gate®” product innovation model Control banding tools and quantitative models will be subject to sensitivity analysis and performance testing followed by a revision as needed. After revision the models will again be analyzed by sensitivity testing, calibration, performance tested to establish the uncertainties. After calibration, the models will be part of the framework, which will be demonstrated by case studies. Stakeholders will be involved for defining the user requirements of the framework and will receive training in the framework at the end. The caLIBRAte project proposal answers to the call of NMP30-2015: Next generation tools for risk governance of MNs. The project is specifically designed to address the key challenges defined in the scope of the call text. There is particular focus on model revision, calibration and demonstration of existing models and methods that support the risk governance framework in regards to safe innovation and already implemented nanomaterials. Next generation computational exposure assessment and -toxicology is anticipated in the framework
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