Manufactured chemicals are essential for the maintenance of public health, food production, and quality of life, including a diverse range of pharmaceuticals, pesticides, and personal care products. The use of these compounds throughout society has led to increasing concentrations and chemodiversity in the environment. Whilst there has been a focus on understanding the impacts of chemicals on a subset of freshwater biodiversity (particularly invertebrates and fish), we understand less about how chemical pollution impacts freshwater microbes. These microbial communities (the 'microbiome') number in the millions to billions of cells per milliliter of water or gram of sediment and form the most biodiverse and functionally important component of freshwater ecosystems. The biogeochemical and ecological functions delivered by freshwater microbes are essential to wider freshwater ecosystem health. The PAthways of Chemicals Into Freshwaters and their ecological ImpaCts (PACIFIC) project will focus on understanding the link between sources of anthropogenic chemicals and their pathways, fate and ecological impacts in freshwater ecosystems, with an emphasis on freshwater microbial ecosystems and the functions they perform. We will investigate the relationship between predicted diffuse and point source chemical pathways and measured chemical concentrations in water and sediments at locations across the Thames and Bristol Avon catchments, chosen to represent gradients of diffuse pollution sources. These locations will be chosen to coincide with Wastewater Treatment Works (WwTWs) to understand how sewage effluent contributes to chemical burden across these gradients. Liquid chromatography coupled with (high resolution) tandem mass spectrometry and QTOF (quadrupole Time-of-Flight) mass spectrometry will be used to perform targeted and untargeted profiling of chemical groups proven and suspected to impact freshwater ecology. A range of microbial community ecosystem endpoints will also be measured at each location to identify the impact of chemical exposure, including bacterial and fungal community composition via DNA sequencing, the expression of nutrient cycling and chemical stress and resistance genes, the production of extracellular enzymes involved with biogeochemical cycling, and the functional gene repertoire of whole microbial communities. We will perform experimental microcosm exposures on freshwater microbial communities, with increasing complexity and realism, deploying high-throughput screening to identify novel chemical groups (and their structural features) with the capacity to restructure these communities. Exemplar microbial community modifying chemicals will be investigated in more detail by applying cutting-edge molecular techniques to determine ecological exposure thresholds that represent different taxonomic and functional aspects of freshwater microbial ecosystems. Novel field-based mesocosms will be used to explore wastewater exposures in more realistic, but controlled settings, allowing us to explore how chemical pollution may interact with other ecological drivers such as nutrients and temperature, and how microbial responses scale up to higher trophic levels and alter ecosystem functioning. Spatially and temporally up-scaled models of diffuse and point source chemical pollution pathways will be combined with novel thresholds developed from the lab and field exposures, to determine chemical threats to freshwater microbes, supporting the development of tools for the better management of the risks of chemical pollution to freshwater ecosystem health. These will be combined with future hydrological, climate, and socio-economic scenarios, informed by responses in our experiments and co-developed with project collaborators, the Environment Agency, to explore future threats to microbial freshwater ecosystems and wider ecosystem health.

Planetary boundaries of river water pollution are at risk of being breached, with dangerous consequences for human and environmental health, economic prosperity, and water security. The current paradigm for environmental management is predicated on understanding of average conditions. However, we know environmental pollution can vary markedly in space and time. This interdisciplinary Large Grant (co-created with non-academic partners and as NERC-NSF collaboration) will pioneer innovations in experimental analytics, data science and mathematical modelling to yield new mechanistic understandings of the dynamic drivers of multi-contaminant pollution hotspots (spaces) and hot moments (times) in a changing water world. The diagnosis of the impact of these locations and periods when average pollution conditions are far exceeded on large scale and long-term river basin water quality is critical to inform local and global adaptation and mitigation strategies for river pollution and develop interventions to keep within a safe(r) 'operating space' and improve water quality for people and the environment. SMARTWATER will therefore integrate environmental sensing, network and data science innovations, and mathematical modelling with stakeholders' catchment knowledge to transform the way we diagnose, understand, predict, and manage water pollution hotspots and hot moments. We will: 1. Pioneer the application of scalable field diagnostic technologies for water quality sensing and sampling for identifying and characterising multi-pollution hotspots and hot moments for emerging (e.g., wastewater indicators, pharmaceuticals, pesticides) and legacy (e.g., nutrients) contaminants. 2. Develop smart water quality monitoring network solutions at river basin scale based on integrating high-resolution networks of proxy water pollution indicators with multivariate UAV boat-based longitudinal river network sampling to understand the footprint, propagation and persistence of pollution hotspots and hot moments in river basins. 3. Develop and apply data science innovations integrating deep machine learning and artificial intelligence approaches for pollution source attribution and to identify how hotspots and hot moments of multi-pollutions dynamics results from pollution source activation, connectivity and river network transport and transformation. 4. Demonstrate the utility of the new generation of smart pollution data to improve the capacity of integrated river basin scale water quality models to adequately present and predict the emergence of pollution hotspots and hot moments including their large-scale footprint and longer-term relevance for catchment water pollution. 5. Co-create with our stakeholder community pathways for successfully implementing practical and policy relevant changes in water quality management practice and use the interdisciplinary and inter-sectoral expertise of our broad stakeholder base to inform knowledge generation and dissemination pipelines in SMARTWATER. The mechanistic process understanding and integrated technological and management solutions that will be developed in SMARTWATER will allow a step change in the diagnostics, prediction and management of water pollution and transform our ability to understand and tackle pollution pressures of increasing complexity in a rapidly changing environment.

London and the South-East is the economic 'powerhouse' of England contributing 40% of GDP. Currently there is a shortage of housing, particularly affordable homes, and 50,000 new homes per year are planned for London to 2036. The growing population of London and its planned housing require water to be supplied and flooding to be reduced as far as possible. However, the region is vulnerable to water shortages (droughts) and floods. In the spring of 2012 London was facing potentially its worst drought, with concerns whether Affinity Water could provide sufficient water for some Olympic events. By contrast, the prolonged rainfall that then fell over the summer caused localised flooding and the Thames barrier being closed twice. This swing, over half a year, from extreme shortage of water to excess highlights the major challenge London faces to manage the water environment. This challenge is likely to worsen with climate change alongside the expected economic growth of London and associated increase in population. It also shows how droughts and flooding are two ends of a hydrological spectrum, whose political oversight, i.e. governance, needs to be managed was a whole. It is this need for integrated, collaborative and appropriate management that lies at the heart of CAMELLIA. Focusing on London, CAMELLIA will bring together environmental, engineering, urban planning and socio-economic experts with governmental and planning authorities, industry, developers and citizens to provide solutions that will enable required housing growth in London whilst sustainably managing water and environment in the city. CAMELLIA will be led by Imperial College London, working in collaboration with researchers at University College London, the University of Oxford, and the British Geological Survey. The programme is supported by communities, policymakers and industry including: local and national government, environmental regulators, water companies, housing associations and developers, environmental charities and trusts. Ultimately, the programme aims to transform collaborative water management to support the provision of lower cost and better performing water infrastructure in the context of significant housing development, whilst improving people's local environments and their quality of life. The relationships between the natural environment and urban water infrastructure are highly complex, comprised of ecological, hydrological, economic, technical, political and social elements. It is vital that policy and management are informed by the latest scientific understanding of hydrological and ecological systems. However, for this knowledge to make a change and have an impact, it needs to be positioned within wider socio-technical and economic systems. CAMELLIA will provide a systems framework to translate Natural Environmental Research Council-funded science into decision-making. Enabling a range of organisations and people to contribute to, and apply systems-thinking and co-designed tools to create a paradigm shift in integrated water management and governance underpins CAMELLIA. This will achieve the goal of real stakeholder engagement in water management decisions and provide a template, not just for London's growth, but for other cities, regions and communities both nationally and globally. The proposed work programme consists of four work packages which address 4 key questions, namely: How to understand the system?; How to model the integrated system?; How to analyse that system?; How to apply this systems approach to create impact? To help focus these questions, four London based case studies are being used, each reflecting a key issue: Southwark (urban renewal); Thamesmead (housing development); Mogden (water infrastructure regeneration); Enfield (Flood risk and water quality). From these, an integrated systems model will be applied to the entire city in order to help guide policy, planning and water management decisions.

RECLAIM is an innovative network to address complex problems and create sustainable, healthy, and liveable urban systems, resilient to climate-related hazards. RECLAIM will become an inclusive platform for continual exchange, and knowledge translation. Our network will connect and transform the 'forgotten cities' to be at the vanguard for environmental and economic advancement using participatory methods and green-blue-grey infrastructure (GBGI) to address societal and environmental challenges. Our vision for RECLAIM is to create a multidisciplinary and cross-sectoral network, which brings together multiple areas of scientific expertise (engineering, ecology, social science), artists, designers, business, city authorities, policymakers and community groups. RECLAIM will act as a hub to rapidly disseminate best practice on GBGI design which takes account of the social and economic context, and the needs of local residents as well as the latest scientific evidence on designing multi-functional GBGI solutions. The network will develop common language, goals and methodology to ease the communication, spreading, and replicability of GBGI. It will focus on the forgotten cities, especially the smaller and/or economically disadvantaged urban areas and communities which have mostly been ignored in the implementation and assessment of GBGI, and making them part of the solution using a participatory approach. The geographical scope is pan-UK, covering some larger cities where good practice is already established (e.g. Liverpool, Glasgow, Newcastle) with smaller cities and less well-off areas in the northeast of England, north Wales, the Midlands and south-east England to test, co-design, engage and learn with their most disadvantaged communities. Disciplinary scope aims to bridge engineering, modelling, atmospheric chemistry, hydrology including marine, green infrastructure, urban art, urban design, and social sciences including science and technology studies. The network has a central aim of addressing the levelling up agenda by incorporating both social justice issues and ecological quality into the design of multi-functional grey, green and blue space in cities, proposed as the means to ensure liveable cities which are sustainable and resilient to the future challenges. It will tackle this through six key objectives, which are delivered through a series of network actions: 1) Build a new multi-disciplinary network to share best practice and act as research leaders; 2) Undertake horizon scanning and knowledge synthesis to identify key gaps in knowledge and make recommendations to address them; 3) Conduct feasibility studies to comprehensively assess new and existing GBGI, and to address knowledge gaps; 4) Design, engage and learn with the public, fostering improved understanding of the wider benefits of green-blue-grey space, and educating the next generation on making our cities more sustainable and healthier places to live; 5) Train a new cohort of decision-makers and academics to embed multi-disciplinary thinking into future GBGI design, incorporating a mix of place-based approaches and scale-appropriate functional interventions; 6) Accelerate uptake of best practices by dissemination through activities designed to share best practice on urban planning and green and blue space design. Underlying this are four cross-cutting themes which thread through all the network activities: Multifunctionality and systems thinking, Embedding aesthetics and people's needs into GBGI design, Upscaling and outscaling, and Capitalising on existing initiatives.