RealCare is a cutting-edge research initiative focused on developing and validating next-generation point-of-care (PoC) systems that detect essential biomarkers in human biofluids in real-time. These systems are designed to be compact, energy-efficient, and integrated with extended reality interfaces, with a specific emphasis on cancer and cardiac diseases in demanding clinical settings. RealCare's approach includes advanced biomarker detection technologies, such as microfluidics and new generations of microneedles, label-free electrochemical biosensors using 2D materials, optical sensors utilizing CRISPR, biological amplifiers combined with fluorescent microscopy, and scalable SPR with energy-efficient electronic readouts, AI data processing, and wireless communication units. Additionally, RealCare will design portable, interoperable, and adaptable PoC systems that integrate the biomarker detection technology with vital sign monitoring, including advanced data analytics and AI methods. The initiative also focuses on developing intuitive extended reality interfaces, such as augmented and virtual reality, to visualize biomarker data in real-time and facilitate rapid medical decision-making in integrated in-care environments and workflows. Rigorous clinical validation studies will be conducted in relevant clinical settings, including the surgery room, ICU, and patient's home, to ensure accuracy, reliability, usability, and impact on patient outcomes. RealCare places special attention on including a diverse patient population in their studies to validate the effectiveness of the developed systems. Data quality, interoperability, and medical data protection are key considerations in RealCare's strategy. Based on our unique PoC technological platform and our strong, multidisciplinary consortium partnership, we propose promising lab-to-market paths with the potential for significant societal impact.

MediaFutures will set up a virtual, European data innovation hub, including funding, mentoring and support for entrepreneurial and creative projects to reshape the media value chain through responsible, innovative uses of data. We will: • explore the critical factors that impact how people engage with bottom-up quality journalism, science education and digital citizenship; • define a participatory, inclusive innovation programme, leveraging impulses from multiple disciplines, as well as synergies between entrepreneurs and creatives; • organise a competition addressing pressing technical, economic and societal challenges in the media value chain to identify promising digital entrepreneurs, creatives and data-empowered solutions; • provide data and experimentation facilities for the winners of this competition to test and nurture their ideas; • support 51 businesses and 43 artists by solving common concerns around funding and access to mentoring in technical, legal, business, media and sustainability matters; and • create toolkits and best practices for innovators, creatives, and other stakeholders to achieve greater traction for their citizen-centric initiatives, and empower them to communicate through data in inspiring, informative and engaging ways. Drawing on the experience of the consortium - ZABALA, ODI and SOTON (instrumental to delivering several flagship Horizon 2020 data incubators); IRCAM (leading the way in publicly funded art-tech-science residencies programmes); EUT and LUH (2 accomplished DIHs and BDVA i-Spaces); NMA (Europe’s largest media accelerator); LUISS (renowned school of journalism and digital startup accelerator); KU Leuven (legal and ethical expert) and DEN (one of Europe’s social innovation pioneers) - we will establish a Europe-wide, virtual data-driven innovation ecosystem, supported and promoted by an international network of 28 organisations that have confirmed their intention to join MediaFutures as members of our stakeholder cluster.

Book publishing is the largest cultural industry in Europe, and European publishing (uniquely among European cultural industries) is a world leader. Nevertheless, the industry needs to revisit its traditional value chains and business models, and to establish effective cooperation with prosumers, to reaffirm its place as a fundamental economic and cultural agent in the digital age. Möbius will contribute to a renewed and invigorated European publishing sector by providing them with methods and tools to leverage the potential of prosumers in innovation processes and thus guaranteeing user-centric and user-driven perspectives in the design and delivery of new enriched media experiences. Möbius will deliver three key innovations: i) Prosumer intelligence toolkit, built upon living labs qualitative methods and the analysis of a dataset containing several hundred thousand of prosumer online works and interactions. ii) Prosumer business models, grounded in thorough analysis of IP law, for steering a fair and sustainable ecosystem; and iii) Möbius book, allowing cross-media, interactive and immersive book experiences. Möbius will developed and validated through large scale piloting activities mobilizing 2.500 relevant user groups, including prosumers, and publishing and media professionals. These innovations will be exploited for direct use and commercialization by partners Bookabook, IN2 and MVB through a Möbius marketplace. Möbius consortium is multidisciplinary, gathering industrial, artistic, social sciences and technological expertise. Möbius will showcase results in two of the largest cultural and technological events in Europe: Frankfurt Book Fair (by MVB) and the Mobile Word Congress (by FMWC). Intense dissemination activities and rigorous impact assessment will be organized to maximize impact of the results in the publishing industry and the European media ecosystem as a whole.

The REBUILD proposal address immigrant integration through the provision of a toolbox of ICT-based solutions that will improve both the management procedures of the local authorities and the life quality of the migrants. The design approach is user-centered and participated: both target groups (immigrants/refugees and local public services providers) will be part of the user requirement analysis and participants in three 2-days Co-Creation workshops organized in the 3 main piloting countries: Italy, Spain and Greece, chosen also for their being the "access gates" to Europe for main immigration routes. Users and stakeholders engagement is a key success factor addressed both in the Consortium composition and in its capacity to engage relevant stakeholders external to the project. The key technology solutions proposed are: GDPR-compliant migrants’ integration related background information gathering with user consent and anonymization of personal information; AI-based profile analysis to enable both personalized support and policy making on migration-related issues; AI-based needs matching tool, to match migrant needs and skills with services provided by local authorities in EU countries and labor market needs at local and regional level; a digital companion for migrants enabling personalized two-way communication using chatbots to provide them smart support for easy access to local services (training, health, employment, welfare, etc.) and assessment of the level of integration and understanding of the new society, while providing to local authorities data-driven, easy to use decision supporting tools for enhancing capacities and effectiveness in service provision. Cross-culturality, ethical, accessibility dimensions will be addressed since the very beginning of the project, and validated and assessed in terms of consistency and impact during the project lifespan.

Brain disorders are the most invalidating condition, exceeding HIV, cancer and heart ischemia, with significant impact on society and public health. Regenerative medicine is a promising branch of health science that aims at restoring brain function by rebuilding brain tissue. However, repairing the brain is one of the hardest challenges and we are still unable to effectively rebuild brain matter. Epilepsy is particularly challenging due to its dynamic nature caused by the relentless brain damage and aberrant rearrangements of brain rewiring. To overcome the biological uncertainty of canonical regenerative approaches, we propose an innovative solution based on intelligent biohybrids, made by the symbiotic integration of bioengineered brain tissue, neuromorphic microelectronics and artificial intelligence, to effectively drive self-repair of dysfunctional brain circuits and we validate it against animal models of epilepsy. HERMES fosters the emergence of a novel biomedical paradigm, rooted in the use of biohybrid neuronics (neural electronics), which we name enhanced regenerative medicine. To this end, HERMES will promote interdisciplinary cross-fertilization within and outside the consortium; it will extend the concepts of enhanced brain regeneration to philosophy, ethics, policy and society to foster the emergence of a new innovation eco-system. Intelligent biohybrids will represent a major breakthrough to advance brain repair research beyond regenerative medicine and neurotechnology alone; it will bring new knowledge in neurobiology, cognitive neuroscience and philosophy, and new neuromorphic technology and AI algorithms. HERMES will bring a giant conceptual leap that will shift the concept of biomedical interventions from treating to healing. In turn, it will potentially generate major returns on health care and society at large by bringing previously unimaginable possibilities to defeat disorders that represent today a global major burden of disease.