Motivated by recent and engaging results showing the fundamental role of chirality in the dynamic of soft matter systems and the technological need of the pharmaceutical industry for chiral differentiation, the CHIRALGHOST research project proposes to examine new possibilities of achieving the separation of enantiomeric entities of various sizes using chiral soft matter systems. The primary objective of this project is to design and implement new experimental systems and theoretical models, based on confined chiral liquid crystals, allowing to specifically determine how the chirality of a fluctuating host environment interacts with the structural chirality of guest objects at the molecular and mesoscopic scales when these objects diffuse or are dragged. More specifically, the possibility of dynamically separating enantiomeric chiral guest molecules diffusing in a confined chiral liquid crystal host will be examined by using specifically designed chiral fluorescent molecules and a combination of fluorescence and light scattering microscopy observations. Moreover, the diffusive and dynamical properties of colloidal particles with a chiral shape and more complex patterns localized in the orientational field of the CLC molecules will be experimentally characterised and quantitatively described in the same confined chiral liquid crystal systems. With a unique combination of experimental and theoretical approaches unlocked by recent advances made by the main coordinator, the CHIRALGHOST project will generate new knowledge regarding multiscale chiral interactions in soft condensed matter. A comprehensive description of chirality-tuned diffusive phenomena in liquid crystals will be established, with a direct impact on the understanding of more complex phenomena such as the self-assembly of chiral objects in complex chiral environments.