Wet waste and long-distance travel are unavoidable consequences of wealthier societies; unfortunately, they both contribute to climate change. Hydrothermal liquefaction (HTL) and biocrude hydrotreating (HT) can convert wet wastes into sustainable aviation fuels (SAF), but for this to become a reality, some pressing challenges need to be addressed. CalSAF is Dr. Matteo Pecchi’s career development program, designed to develop differential scanning calorimetry (DSC) methods that can provide high-resolution information on the HTL and HT process development in-situ, at a fraction of the cost of traditional methods using batch reactors and chemical analyses. Dr. Pecchi’s training is supported by an international collaboration of world-leading universities and experts in the hydrothermal field, leveraging their cutting-edge experience and equipment. This collaboration aims to facilitate his transition into an independent researcher and expert in thermochemical processes for waste valorisation, which is central to his long-term career goals. If successful, CalSAF will uncover new insights into the mechanisms and kinetics of HTL and HT, addressing key challenges that currently hinder industrial SAF production from wet waste. These challenges include the high costs and time associated with HTL screening campaigns and the lack of data for effective control to prevent clogging in HT reactors. The impact on both waste management and fuel production sectors will generate significant environmental, social, and economic benefits, including reducing emissions, decreasing pollution and health risks, and opening a potentially multi-million-euro market.