The SAFARI project aims to develop new 2D materials using sustainable and safe processes. The project focuses on creating hybrid formulations of MXenes and Graphene (Gr), which are known to possess unique and desirable properties such as thermal stability electrical conductivity. The goal of the project is to develop sustainable and safe materials that can be used in a wide range of applications such as biosensors, conductive ink, and EMI shielding. The SAFARI project begins with the preparation of precursor compounds known as MAX phases. These compounds are then used to produce two types of MXenes (Ti3C2 and Cr2C) which are further functionalized to enhance their properties and increase their affinity with Graphene. The resulting 2D hybrid materials are created using two different methods, and their structural, morphological, and functional properties are thoroughly examined. One of the main strengths of the SAFARI project is that is allinged with the SSbD principles. Thus assessment of the toxicological and eco-toxicological profiles of the new materials through a range of tests and assays will be conducted. In conclusion, the SAFARI project represents a significant step forward in the development of 2D hybrids with MXenes/Graphene for use in a wide range applications.