The CHIMERA project will provide a ground-breaking solution to the selected shortcomings and gaps in the CBRN security market. The project aims to do so by developing a multiplatform Command & Control CBRNe system for responders, dispatch and crisis centres providing an area of interest overview, asset management, and real-time data visualization, as well as by developing a multipurpose heterogeneous sensor node for CBRNe detection allowing for the integration of commercially available detection instruments. Furthermore, the project aims to implement a real-time dispersion modelling software for C&R agents to provide dispersion models and source estimations considering the 3D urban environment, and to integrate data fusion algorithms combining data from different sensors from chemical, radiological or biological layers to enable agent identification and false alarm reduction. Ultimately, the CHIMERA project will create a commercial-ready database combining C, B and RN substance/agent characteristics. With these solutions, the project’s outcomes will considerably enhance both the operational capabilities of the first response and crisis management teams and the safety of the on-site personnel. All project-developed components will function as individual units as well as part of the whole system. In addition, the CHIMERA system will feature an open design to enhance its interoperability and facilitate other existing systems integration. To illustrate the system’s potential for real-world application, it will be demonstrated before a live audience of stakeholders, industry representatives, and potential end-users in a realistic scenario.