The Young International Academics postdoctoral programme (YIA) is a career development program proposed by the University of Luxembourg (Uni.lu) to nurture early-career postdoctoral applicants to gain momentum in interdisciplinary/intersectoral research. YIA applicants are international talents willing to propose and realize their own interdisciplinary research projects through a bottoms-up approach. YIA will welcome, in two calls, a total of 10 postdoctoral fellows with 36-month contracts over 5 years. YIA is open to all disciplines and sectors, involving Uni.lu in the drive towards an increased interdisciplinarity and intersectorality, which are strategic for Uni.lu, for the country and for Europe. A unique aspect of YIA is its integration into Uni.lu’s Institute for Advanced Studies-Luxembourg (IAS) created in 2019 to promote interdisciplinarity and outreach towards the society. This integration provides the YIA fellows with (1) a supervision for interdisciplinary and intersectoral research with more than 350 potential (co)-supervisors, and with about 350 potential public-private partners, (2) peer and cross-generational interactions/mentoring through the IAS fellows, invited distinguished senior scientists, early career researchers, and a mandatory academic or industrial secondment, and (3) a truly international flavour in an environment that cherishes diversity and excellence. YIA fellows recruited at Uni.lu are offered competitive contracts with mobility fellowships and access to excellent research infrastructures. A professor of Uni.lu provides supervision for the primary discipline of the applicant’s project and a co-supervisor covers the complementary discipline/sector. The YIA fellows are offered an “à la carte” training including mandatory courses, to suits the fellow’s career aspirations, increase the fellow’s interdisciplinarity and employability. The YIA programme will support a rapid ramp into a long-term Uni.lu funding of postdoctoral IAS fellows.