ARISE will make industrial HRI deployments simpler, cheaper, and more widespread in Europe by developing and demonstrating the concept of AgileHRI. The ARISE project envisions a near future which aligns with the principles of Industry 5.0, prioritising resilient, sustainable, and human-centric work environments. In such a future, companies recognise that investing in industrial human-robot interaction (HRI) is essential for achieving better short- and long-term goals, rather than a cost. Human-centric approaches surpass traditional technology-driven approaches, with technology serving people rather than the other way around. Industrial HRI establishes its position as a game-changing asset that enables seamless collaboration between humans and robots on complex tasks, allowing them to work together in shifts of any length. On its way to materialise such a vision, the ARISE project will i) address major application challenges from today’s industry, ii) develop human-centric solutions, tools, and software modules which expand the state-of-the-art in industrial HRI, and iii) deploy industrial HRI at scale in four testing and experimentation facilities and more than 25 workplaces across Europe (FSTP Projects). The ARISE project will address these challenges using cutting-edge open-source technologies from the European innovation ecosystem and will make a significant adavance on their state-of-the-art to position Europe globally at the forefront of industrial HRI. To that aim, the project will put the focus on the achievement of four major goals: (1) to increase the efficiency and cost-effectiveness of developing, deploying, and maintaining HRI solutions; (2) To develop open-source based reusabmodules which push industrial HRI beyond the SotA; (3) to demonstrate openness and agility as crucial enablers of truly valuable and sustainable HRI solutions; (4) to ensure impact a and sustainability through a critical mass of stakeholders & strong liaisons with ADRA ecosystem.