DIHs are one-stop-shops that help companies to become more competitive with regard to their business and production processes, products or services using digital technologies. DIHs have the mission of helping companies to betteDIHs are one-stop-shops that help companies to become more competitive with regard to their business and production processes, products or services using digital technologies. DIHs have the mission of helping companies (mainly start-ups, SMEs and mid-caps) to better understand and experiment on how digital technologies can improve their efficiency, effectiveness and product quality – in other words, their competitiveness. DIHs should have strong linkages with service providers outside of their own region in order to support companies in those services and technologies where regional DIHs do not have the requested in-house resources to provide services based on specific technologies sought by users. In recent decades, health-related activities have evolved from a reactive approach (curing diseases) to an approach based on the P4 medicine paradigm: Predictive, Preventive, Personalised and Participatory. In this new paradigm, the use of digital technologies is key. Thanks to digital technologies such as AI or HPC and the massive generation of medical and other health-related data, traditional methods for early detection, diagnosis, treatment, patient management, precision medicine, drug development, genomics, or medical image analysis are being transformed. DIHsP4_MEDICINE project aims to unleash the potential that exists around the collaboration among DIHs focused in health-related activities. The lessons to be learned from the activities carried out within the framework of the project will make possible to take advantage this experience for the implementation of joint long-term and stable programmes to fostering collaboration among DIHs, as well as exploring the opportunity to articulate stable Hub corridors to shape these collaborations.