This is a proposal to host SET Plan Conference 2022 in the Czech Republic during the Czech Presidency of the EU. The Conference will take place in Prague on 9 - 10 November 2022. The programme is dived into several thematic sessions dedicated to e.g. low-carbon sources, industry, buildings, hydrogen, CCS etc. There will be a high-level panel where we expect the attendance of Commissioners Simson and Gabriel. Minister of Industry and Trade will also be present. The first day will be closed by an informal dinner. The Conference should promote research and innovation in the EU and enable discussions among different researchers. A result should be recommendations on the future orientation of the EU research and innovation programmes.