Manufacturing industry faces the challenges of driving competitiveness, resilience, sustainability and circularity in the context of a Volatile, Uncertain, Complex and Ambiguous environment. A VUCA world calls for new capabilities on the manufacturing systems demanding HUMANufacturing systems to evolve from industrial automation towards industrial autonomy. MaaS technologies still lack a solid foundation for more active resilience mechanisms that can respond with increased agility to more volatile and uncertainty scenarios. M4ESTRO envisions to create an end-to-end trustworthy and transparent platform for Manufacturing as a Service offering active and predictive resilience and timely preparedness to disruptive events. M4ESTRO will foster an interactive, collaborative, and dynamic ecosystem where these stakeholders will operate in a hyper-distributed way to manufacture products by providing and receiving services in a secure and trusted manner. It will offer response actions to foreseen risk based on the intrinsic network’s flexibility while offer preparedness to unforeseen risks based on the documented resilience to switch action plans To do so, M4ESTRO will focus on four (4) pillars, offering HW and SW components: Pillar 1: Resilient, transparent and flexible manufacturing processes in value chains. Pillar 2: Resilient equipment, AI and trusted data for adaptive manufacturing. Pillar 3: Resilient Simulations to the Industrial Metaverse for responsive manufacturing. Pillar 4: Human centred Manufacturing Resilience and Sustainability. The impact of M4ESTRO for the European Manufacturing industry, but also the society itself, can be summarised in the following (with a horizon of 4 years after project ends): (i) Process ramp-up time (>26%); (ii) OEE (>14%); (iii) Yield & CpK (>11% & >24%); (iv) Product cost reduction (>9%); (v) Cost per piece (>38%); (vi) Energy consumption (>26%); (vii) about 305 new jobs created and (viii) over 42.89 MEUR ROI for the consortium.