Transforming agriculture in the context of climate change is a central challenge in North-Africa, the most food-import-dependent region worldwide and a climate change hotspot. Tackling these issues, Agro-Ecology (AE) appears as an answer to meet both the challenges of global sustainability and local resilience. In this context, NATAE consortium brings together high-level research institutions, international organisations and NGOs with strong experience on AE approaches and exceptional capacity to induce transformational change by informing policies and education. NATAE project aims to foster the adoption of science-based, locally-tailored and co-designed AE strategies in North Africa by creating a comprehensive and quantitative baseline on AE, providing a shared understanding, multidimensional performance measures, and analyses of AE potential for meeting consumers demand on the market. To achieve this goal, NATAE will set-up and inform a unique multi-actor community of knowledge and capacity building on AE in the Mediterranean, with ground breaking findings on the performances of AE-Practices (AEP) in North Africa. An original multi-dimensional, multi-scale evaluation framework covering dimensions currently overlooked, and a replicable methodological guidebook will be designed. An integrated modelling approach combining a biophysical, a household/regional bio-economic indicator modelling chain will be used to develop a unique Integrated Assessment of Agricultural Systems to assess the resilience of AEP-based farming systems. Participatory approaches via Living Labs will be elaborated to develop, test and capitalize alternative public policies and foster AE transitions. An integrated group of dissemination activities, will further test, advance and communicate a range of existing AE innovations from farm to fork, including innovative farm practices, value-chain innovations, and innovations in food system governance, advancing their respective readiness level.