The MASTERPIECE project aims to create a transformative change in the conservation of Wooden Panel Paintings (WPPs) from the Middle Ages and Renaissance, integral to our shared cultural heritage. These artworks are susceptible to environmental conditions like humidity and temperature fluctuations, challenging traditional conservation methods. The project proposes an innovative approach by integrating energy-efficient climate control and advanced digital modeling to optimize both preservation and sustainability. Traditional climate control systems in museums contribute to an unsustainable energy footprint. MASTERPIECE addresses this by using adaptive climate control strategies that take into account the unique needs of each artwork. Through collaboration with the Getty Conservation Institute (GCI), a leader in art conservation, the project will develop 'digital twins'—digital replicas that simulate the artworks' hygro-mechanical behavior in real-time. Rather than focusing solely on vulnerability, MASTERPIECE introduces the concept of resilience through 'fragility-resilience curves.' These curves enable a nuanced understanding of how artworks respond to environmental stressors, informing targeted and effective conservation strategies that harmonize with energy efficiency goals. The project will unfold in two key phases. The first phase at the GCI will focus on creating the digital twins and fragility-resilience curves. The second phase will conduct mechanical characterization tests on historical paintings to validate and refine these models, ensuring their broader applicability and impact. MASTERPIECE aims to redefine standards in art conservation by offering an interdisciplinary solution that harmonizes the need for energy-efficient practices with effective long-term preservation. By integrating advanced technologies with conservation science, MASTERPIECE aspires to make a lasting, positive impact on global art preservation strategies.