The Solanaceae family, encompassing economically significant genera like Solanum, plays a vital role in global agriculture, particularly through crops. The Solanaceae family, encompassing economically significant genera like Solanum, plays a vital role in global agriculture, particularly through crops like potatoes and tomatoes. These crops, crucial for human consumption and nutrition, face significant threats from pest diseases, with annual losses amounting to billions of euros. Notably, the bacteria Clavibacter sepedonicus – Cs (ring rot in potato) and Ralstonia solanacearum - Rs (bacterial wilt in potato and tomato) pose severe economic and environmental risks, warranting stringent regulatory measures in EU and globally being included in Part B Annex of the Regulation 2019/2072 and are classified as EPPO A2 quarantine pests. In response, the POMATO project aims to safeguard potato and tomato health by focusing on four key pillars: isolation and molecular characterization of resistance genes of potato and tomato native and wild varieties against Cs and Rs, early detection using advanced technologies like AI and digital predictive platforms, development of natural bio-control solutions, and field validation at TRL 5 of the Integrated Pest Management (IPM) strategies. This collaborative 48-month initiative involves a multi-actor approach of the potato/tomato value chain, including academic research institutions, agrochemical companies, farmers, and international partners from affected regions like Latin America. By leveraging expertise and resources, POMATO seeks to mitigate the spread of these quarantine pests and enhance food security sustainably by aiming to decrease between 40-60% the incidence of Cs/Rs. Sharing IPM POMATO’s strategies among relevant stakeholders in the policy and decision-making cycle will ensure economic sustainability of EU potato/tomato production, increase farm competitiveness as well as replicate the outcomes of the project to other crops.