Transformative adaptation is gaining recognition as the appropriate response to climate change as the current adaptive measures reach their limits. In addressing health risks associated with heat waves, air pollution, wildfire emission and pollen, the implementation of comprehensive transformative adaptation remains largely unreported in Europe. healthRiskADAPTs objective is to develop and implement a health risk assessment system for Mediterranean, Alpine and Continental regions. Its contents and tools will be in line with Climate-ADAPT described Urban adaptation support tool. This will support empowerment of local and regional authorities to make informed decisions in strategic planning, management and daily operational mitigation of health challenges related to climate change. healthRiskADAPT will address the fundamental causes of vulnerability and implement concrete adaptation measures aiming to mitigate the health impacts of climate change. The key details of this approach include: 1) Co-creation with users of integrated transformative adaptation options encompassing technical, nature based, and social solutions, reducing the impact of climate-related risks on human health in both indoor and outdoor environments. 2) Vulnerability assessments, health indicators, and risk indices related to climate change impact on health, considering different temporal and spatial scales. 3) Interactive and user-friendly toolkit for local & regional authorities to assess hazards, vulnerability, and risks specific to their regions. These toolkits will facilitate the prioritization, planning, and evaluation of adaptation options. healthRiskADAPT will use various communication techniques to actively engage with all stakeholders involved in the adaptation process, and develop an upscaling strategy to meet the ambitions of the Climate mission. Furthermore, we seek to enhance the preparedness of the healthcare system to respond effectively to the challenges posed by the effects of climate change.