Despite efforts to reduce fragmentation across the European Research Area, the European scientific system is still facing challenges in achieving gender equality and gender mainstreaming in research and innovation. In this context, and in line with ERA policy goals and national contexts, the GENDER-NET Plus ERA-NET Cofund aims to strengthen transnational collaborations between research programme owners and managers, provide support to the promotion of gender equality through institutional change and instigate the integration of sex and gender analysis into research and funding programmes. To do so, project partners – a consortium of 16 committed organisations – will join forces to 1) Implement a joint co-funded call for proposals, 2) Design and implement transnational actions on the promotion of gender equality through institutional change and the integration of sex and gender analysis into research, 3) Update and enlarge the mappings and analyses carried out in GENDER-NET on the promotion of gender equality in research and innovation, 4) Carry out a joint assessment of gender differences and bias in access to research grants and define and develop appropriate conditions for promoting equal opportunities in research funding, 5) Promote and disseminate key findings. GENDER-NET will address these goals through 7 work packages and relies on a strong transnational cooperation between partner EU Member States, Associated Countries, and Third Countries, to contribute to the advancement of gender equality in the ERA.