This proposal seeks funding under the Horizon 2020 Work Programme to establish an ERA-NET for International Coordination of Research on infectious Animal Diseases (ICRAD). The scope for this ERA-NET has been developed under the SCAR Collaborative Working Group on Animal Health & Welfare Research (CWG AHW), which seeks to build further on 2 previous successful ERA-NETS (EMIDA, ANIHWA). 31 partners from 20 countries initially seek to support one co-funded call followed by other joint activities including the update of the EU Animal Health Strategic Research Agenda and the initiation of new international partnerships. Animal diseases cause severe social, economic and environmental damage and in some cases threaten human health as well. Disease threats to the livestock industry have increased in the last decades due to globalisation, altering production methods, climate changes and increased contacts between wildlife and livestock. Effective control tools or key knowledge leading to better control is still missing for many important livestock diseases, including for African Swine Fever and animal influenza which pose great challenges in Europe and globally. Partners in this ERA-NET will address these threats through joint European research within a framework which supports multi-disciplinary research in the fields of (i) fundamental understanding of host/(vector)/pathogen interactions and the epidemiology of disease; (ii) vaccinology and (iii) diagnostics. Research and innovation coordinated through ICRAD will (i) increase preparedness and ability to respond to emerging and endemic livestock threats; (ii) provide improved vaccines and diagnostic tools and strategies; (iii) contribute to the reduction of antibiotic and antiparasitic resistance; and (iv) contribute to animal welfare by better disease prevention. By reducing the burden of animal disease and its impact on international trade, ICRAD will enhance food security and sustainable livestock production.