PRECEPT ambitiously aims to set the grounds for the deployment and operation of proactive residential buildings. The proposed framework introduces a “plug-n-play” Pred(scr)ictive and Proactive building energy management system (PP-BMS) installed locally at building level, at the Edge-Enable Proactiveness (EEP) device. The proposed PP-BMS is self-adapted, self-learned, -managed, -monitored, -healing and -optimized, requiring no (or minimum) installation costs and no maintenance. PP-BMS transform traditional reactive buildings to proactive ones, increasing their performance (both energy efficiency and occupants’ well-being), exploiting RES, storage, forecasts and energy tariffs. PRECEPT also targets to the development of a real-time digital representation of the intelligent proactive residential buildings by employing 6D BIM technology. Further to that, a set of novel indicators leveraging on the smart readiness rationale will be introduced for rating the Smart Proactiveness of buildings. The proposed indicators will enable the introduction of a reliable framework under which the comparative assessment of the level of smartness and proactiveness of buildings can be regulated and assessed. Also, PRECEPT approach will deliver advanced data visualizations, utilizing big-data and visual analytics techniques, which in conjunction with a social collaboration platform will engage stakeholders to exchange best-practices. Interaction with the grid will be supported in a secured (Hyperledger Fabric) manner through the decentralized EEP device, supporting the implementation of D/R strategies. To maximize its potential impact, PRECEPT demonstrates novel sustainable business models for rendering traditional reactive buildings to proactive buildings that go beyond the energy-related benefits and cost-optimal analysis but include occupants’ well-being, and other services. PRECEPT framework will be demonstrated in relevant environments in 5 use cases, including 250 apartments.