The 3-year CAFIPLA project will radically alter the biomass pre-treatment approach for bio-economy applications. Current biomass use comes at a high cost, either in terms of land use (sugar/starch crops) or energy and chemical use (2nd generation biomass). On the other hand, bio-waste is massively produced in urban or rural context but almost not valorised, or solely in low-value applications, in part due to its heterogenous nature. CAFIPLA tackles both issues by developing an integrated biomass valorisation strategy that combines the carboxylic acid and fibre recovery platform (CAP/FRP). CAFIPLA firstly optimises the separation of the easily biodegradable fraction and recalcitrant biomass, as input for the CAP and FRP, respectively. This allows the implementation of tailored valorisation strategies for both routes, which in turn allows the use of heterogeneous biowaste as input, while still ensuring high overall yields. In the CAP, research will focus on process control strategies to obtain specific spectra of carboxylic acids to feed into bioproduction of microbial protein, PHA or caproic acid biooil. In the FRP, fractionation into different fibre ranges will result in intermediates that can be valorised as packaging material or insulation. A TRL5 pilot will demonstrate the CAFIPLA upscaling potential. CAFIPLA represents a radically new approach for bio-economy applications by approaching biomass use more pragmatically. This approach, which centres on the integration of two platforms, allows tailor-made solutions. This improves the sustainability and cost-effectiveness of pre-treatment (ambient pressure/temperature, low chemical use, bio-waste as input material). CAFIPLA will furthermore study the biomass supply chain and the business models for future implementation. The well-balanced consortium, including 7 SMEs on 13 participants, will ensure successful research and impact on the bio-economy well beyond the project consortium and timing.