Food and nutrition security (FNS) remains a challenge for Africa, despite efforts made in agricultural research and extension in the past, due to inefficient implementation and exchange of technologies and knowledge to end users. The main objective of InnovAfrica is to improve FNS by integrating sustainable agriculture intensification (SAI) systems, innovative institutional approaches (IIAs) with novel extension and advisory services (EASs) and enhancing smallholder adaptive capacity in Sub-Saharan Africa (SSA). InnovAfrica addresses main challenges of the work programme (SFS-42-2016), through a strong multidisciplinary EU-Africa consortium of 16 partners, supported by 6 active Multi-Actor Platforms (MAPs) in 6 case countries (Ethiopia, Kenya, Malawi, Rwanda, Tanzania and South Africa). InnovAfrica will test, integrate, and disseminate SAI systems suitable to smallholders, institutional approaches (e.g. MAPs, seed delivery systems) and EASs (e.g. dynamic knowledge platforms supported by smart phones, Village Knowledge centers). The main outcomes of InnovAfrica include: i) better understanding of the needs and opportunities of SAI systems in Africa, ii) improved knowledge and innovation capacity of farmers to implement SAI systems supported by IIAs and EASs, iii) improved product value chains through viable IIAs benefiting women and youth, iv) Innovative policies, increased knowledge of public-private partnerships to strengthen agri-business model in case countries with a view to upscaling successes in other regions through functional MAPs, v) Wider dissemination of SAI systems to smallholders and women within and outside project areas through effective use of smart phones and social media, and vi) Stronger EU-Africa Research and Innovation Partnership to achieve FNS. The outcomes will contribute to smallholder productivity, profitability; and nutritional benefits while reducing negative environmental impacts and enhance FNS and sustainable agriculture in Africa.