The promotion of Biotechnology adapted to the needs and priority problems of Tunisia will help reduce its dependence on the outside world and promote its autonomy. The emergence of new technologies in the Biotechnology has encouraged the renewal of industrial strategies and the growth of innovative companies creating new jobs. The present project aims at modernizing higher education, strengthening the LMD reform and consolidating the quality of education in Tunisian biotechnology institutes in order to improve the qualifications and qualification of graduates in order to guarantee a better insertion rate in the labor market in various sectors: pharmaceutical, cosmetic, food and environmental industries. It aims particularly to make the training courses in the biotechnology paths more professional to match the needs of the world of work and thus optimize the employability, the speed of integration and the entrepreneurship spirit of graduates. This project proposal aligns with higher education reforms in the partner country (Tunisia) which promote university-business cooperation and encourage new learning methods based primarily on entrepreneurship. The project will be enriched by the contributions of the European universities members of the project through the transfer of expertise and good practices for quality training compatible with European standards and meeting the socio-economic needs of Tunisia.