Acute wound healing involves a tightly regulated cascade of cellular signalling and functional events. Deterioration at any stage of this sophisticated system can lead to healing impairment and chronic, non-healing wounds. Chronic wounds, which are prevalent in the elderly and diabetic, are a global socioeconomic burden and remain a major area of clinical unmet need. Improved understanding of the cellular and molecular aetiology of chronic wounds is essential to develop new therapies. The aim of this projcet is to explore the role of cellular senescence and the metallome in governing normal and pathological wound repair.