Nutrition security, health and environmental systems are closely interlinked and need to be jointly managed. This requires long-term monitoring and observations systems, modelling and assessment tools, as well as integrated technological and institutional solutions. NUTRI-SCOPE will link global-scale, long-term scenarios on the food system under socio-economic and environmental change with a well-selected sample of empirical sub-national assessments of nutritional impacts in children under five. Bridging global and sub-national scales will be facilitated by specific national socio-economic assessments. Within the existing INDEPTH network of long-term health and demographic surveillance systems we will determine the causal relationships between environmental changes, food availability, nutritional status and health indicators. The derived impact functions will be used in national and global-scale models to generate future scenarios on nutrition and public health under socio-economic and environmental changes. With this modelling framework, integrated technological and institutional solutions for improving nutrition security and health will be assessed, contributing to improved policy decisions. The initial focus will be on six countries in Africa and Asia, including ground-truthing of modelling results. The long-term goal is to establish an integrated, multi-scale monitoring and assessment framework at the interface between the global food system, public health, nutrition, and environmental change.